Anxiety is a common comorbidity for those with autism. There are numerous ways to alleviate or overcome anxiety. Inositol has been used so let's understand the indications of need, mechanism of action, clinical trial data of inositol in those with autism and dosing.
Indications of Need:
Obsessive compulsive disorder (OCD)
Can't fall asleep
What is inositol?
Inositol was once considered to be Vitamin B8 but it’s not classified as a vitamin anymore. >>> Found in citrus fruits and other vegetables
Inositol is involved in many aspects of functions in our body.
The brain is highly sensitive to inositol depletion. The blood–brain barrier limits the availability of plasma inositol, making it dependent on inositol recycling and synthesis.
Inositol exerts an effect on serotonin levels.
SSRIs block the reabsorption (reuptake) of serotonin in the brain, making more serotonin available. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters. SSRIs also may be used to treat conditions other than depression, such as anxiety disorders.
Inositol & Autism
Research of a clinical trial with inositol in those with autism was published in 1997.
A controlled double-blind crossover trial of inositol 200 mg/kg per day showed no benefit in 9 children with autism.
Although they did comment that higher dosing should be examined.
No other clinical trial data is published on inositol and autism. One reason why healthcare practicioners recommend inositol is that it can be taken during the high anxity situation.
If the indications of need align with your child's symptoms be sure to discuss this with your healthcare practicioner.